Zalicus completed Phase 1 pharmacokinetic and safety studies and has picked the optimal formulation to move into further clinical development, the company said. The selected formulation demonstrated a six-fold improvement in Z160's bioavailability compared to the previously studied formulation of Z160.
"The lack of adequate pain control in patients with chronic neuropathic pain represents a significant unmet need and important opportunity for novel agents with improved tolerability, enhanced efficacy, and better long-term safety profiles," said Mark Corrigan, Zalicus president and CEO.
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