Orthobiologics company Kuros Biosciences has treated the first patient in its clinical trial evaluating Fibrin-PTH for transforaminal lumbar interbody fusion in patients with degenerative disc disease.
Fibrin-PTH is a drug-biologic that promotes bone growth through the induction of osteoprogenitor cell differentiation, enhancement of osteoblast proliferation and increasing the lifespan of bone-forming cells.
University of California San Diego's Richard Allen, MD, PhD, principal investigator of the study, treated the first patient.
The phase 2 study is evaluating the technology for both open and minimally invasive surgical techniques.
Fifty patients will be enrolled in the trial, with those treated with local autograft acting as controls.