A Columbia University professor, Helen H. Lu, PhD, won a three-year $1.125 million Translational Research grant to study tendon-to-bone integration for rotator cuff repair, according to News-Medical.
Here are five highlights:
1. The Department of Defense's Congressionally Directed Medical Research Programs awarded Dr. Lu the grant.
2. In the study, Dr. Liu will collaborate with William Levine, MD, chairman and Frank E. Stinchfield Professor of orthopedic surgery at New York-based Columbia University Medical Center.
3. Drs. Liu and Devine will use the funding in preclinical trials to test the potential of a nanofiber-based device to allow biological healing between tendon and bone post rotator cuff surgery.
4. To address the unmet clinical demand for integrative rotator cuff repair technologies, Drs. Lu and Devine and their students devised an innovative approach that focuses on the regeneration of the tendon-to-bone interface through the design of a biomimetic nanofiber scaffold together with controlled stem cell differentiation.
5. Current strategies do not have the mechanical integrity and structural make-up needed for tendon-bone healing, therefore limiting their clinical use.
"Given that the predominant reason for repair failure and requisite revision surgery is the lack of functional tendon-to-bone integration, our new approach represents a paradigm shift and will improve how tendons are repaired clinically," Dr. Levine writes.
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